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Jump to BCS classes - According to the Biopharmaceutical Classification System (BCS) drug substances are classified to four classes upon their solubility and permeability: Class I - high permeability, high solubility. Class II - high permeability, low solubility. Class III - low permeability, high solubility. J Control Release. 2017 Feb 28;248:71-95. Doi: 10.1016/j.jconrel.2017.01.014. Epub 2017 Jan 11. BCS class IV drugs: Highly notorious candidates for. Jul 31, 2018 - BCS Class IV drugs: Highly notorious candidates for formulation development. BCS class IV drugs (e.g., amphotericin B, furosemide, acetazolamide, ritonavir, paclitaxel) exhibit many characteristics that are problematic for effective oral and per oral delivery. Feb 28, 2017 - Based on the BCS, drugs are classified into four categories according to their solubility and permeability properties as follows; high solubility–high permeability (class I); low solubility–high permeability (class II); high solubility–low permeability (class III); and low solubility–low permeability (class IV) [3].
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